Article
Post-transcriptional gene regulation by HuR promotes a more tumorigenic phenotype.
Oncogene - 16 Oct 2008
Mazan-Mamczarz K, Hagner P R, Corl S, Srikantan S, Wood W H, Becker K G, Gorospe M, Keene J D, Levenson A S, Gartenhaus R B
Abstract excerpt
In a breast tumor xenograft model, the MCT-1 oncogene increases the in vivo tumorgenicity of MCF7 cells by promoting angiogenesis and inhibiting apoptosis. Increases in the tumor microvascular density are accompanied by a strong reduction in the levels of the angiogenesis inhibitor thrombospondin-1 (TSP1), but the mechanisms underlying this process are unknown. We show that TSP1 expression is controlled, at least...
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