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Article

Crystallization of HLA-DR antigens.

Research in immunology - 1 Jan 2000

Gorga J C, Brown J H, Jardetzky T, Wiley D C, Strominger J L

Abstract excerpt

The class II major histocompatibility antigens HLA-DR1, DR2, DR3, DR4, DR7 and DR8 were purified by immunoaffinity chromatography from homozygous human B lymphoblastoid cell lines. The purified, detergent-soluble molecules were cleaved with the protease papain to remove the hydrophobic transmembrane regions and cytoplasmic tails. Crystals were obtained for each of the papain-solubilized fragments. DR1...

Topics

Alleles
Chromatography, Affinity
Chromatography, Gel
Crystallization
Crystallography
Electrophoresis, Polyacrylamide Gel
HLA-DR Antigens
Humans
Hydrogen-Ion Concentration
Tumor Cells, Cultured

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Identifiers

PMID: 1754711
DOI: 10.1016/0923-2494(91)90038-k

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1754711-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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