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Article

Backdoor pathway for dihydrotestosterone biosynthesis: Implications for normal and abnormal human sex development

16 Oct 2012

Abstract excerpt

We review the current knowledge about the "backdoor" pathway for the biosynthesis of dihydrotestosterone (DHT). While DHT is produced from cholesterol through the conventional "frontdoor" pathway via testosterone, recent studies have provided compelling evidence for the presence of an alternative "backdoor" pathway to DHT without testosterone intermediacy. This backdoor pathway is known to exist in the tammar...

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Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
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PMID: 23073980
DOI: 10.1002/dvdy.23892

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