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Classic and backdoor pathways of androgen biosynthesis in human sexual development

29 Jun 2022

Abstract excerpt

Both genes and hormones regulate human sexual development. Although ovarian hormones are not essential for female external genitalia development, male sexual development requires the action of testicular testosterone and dihydrotestosterone (DHT). DHT is the most active endogenous androgen formed by the conversion of testosterone in genital skin. This synthesis route from cholesterol to DHT is called the...

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PMID: 35793998
DOI: 10.6065/apem.2244124.062

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