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Article

Mutation-specific IDH1 antibody differentiates oligodendrogliomas and oligoastrocytomas from other brain tumors with oligodendroglioma-like morphology.

Acta neuropathologica - 1 Feb 2011

Capper David, Reuss David, Schittenhelm Jens, Hartmann Christian, Bremer Juliane, Sahm Felix, Harter Patrick N, Jeibmann Astrid, von Deimling Andreas

Abstract excerpt

Isocitrate dehydrogenase 1 (IDH1) mutations are frequent in astrocytomas, oligoastrocytomas and oligodendrogliomas. We previously reported the generation of a mutation-specific antibody that specifically detects R132H mutated IDH1 protein (clone H09). Here, we investigate the feasibility of H09 immunohistochemistry to differentiate between oligodendrogliomas/oligoastrocytomas and other tumors with similar...

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Identifiers

PMID: 21069360
DOI: 10.1007/s00401-010-0770-2

Genes

IDH1
IDH2

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