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Article

Analgesia and central side-effects: two separate dimensions of morphine response.

British journal of clinical pharmacology - 1 May 2013

Droney Joanne M, Gretton Sophy K, Sato Hiroe, Ross Joy R, Branford Ruth, Welsh Kenneth I, Cookson William, Riley Julia

Abstract excerpt

AIMS: To present a statistical model for defining interindividual variation in response to morphine and to use this model in a preliminary hypothesis-generating multivariate genetic association study. METHODS: Two hundred and sixty-four cancer patients taking oral morphine were included in a prospective observational study. Pain and morphine side-effect scores were examined using principal components analysis....

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Source

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Identifiers

PMID: 23072578
DOI: 10.1111/bcp.12008
PMCID: PMC3635604

Genes

OPRD1
OPRK1
OPRM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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