Article
The Association between genetic variations of CHI3L1, levels of the encoded glycoprotein YKL-40 and the lipid profile in a Danish population.
PloS one - 1 Jan 2012
Thomsen Stine Brinkløv, Rathcke Camilla Noelle, Skaaby Tea, Linneberg Allan, Vestergaard Henrik
Abstract excerpt
BACKGROUND: The inflammatory biomarker YKL-40 seems to play a role in atherosclerosis and is elevated in patients with obesity, cardiovascular disease and type 2 diabetes. Single nucleotide polymorphisms (SNPs) of the YKL-40 encoding gene, CHI3L1, are associated with inter-individual YKL-40 levels. One study has described an association between a promoter polymorphism of CHI3L1 and levels of low density...
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