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Article

The familial risk and heritability of multiple sclerosis and its onset phenotypes: A case-control study.

Multiple sclerosis (Houndmills, Basingstoke, England) - 1 Sept 2023

Boles Graysen Steele, Hillert Jan, Ramanujam Ryan, Westerlind Helga, Olsson Tomas, Kockum Ingrid, Manouchehrinia Ali

Abstract excerpt

BACKGROUND: The two main phenotypes of multiple sclerosis (MS), primary progressive (PPMS) and relapsing Onset (ROMS), show clinical and demographic differences suggesting possible differential risk mechanisms. Understanding the heritable features of these phenotypes could provide aetiological insight. OBJECTIVES: To evaluate the magnitude of familial components in PPMS and ROMS and to estimate the heritability...

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Identifiers

PMID: 37435869
DOI: 10.1177/13524585231185258
PMCID: PMC10503245

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