Article
No association of DPP6 with amyotrophic lateral sclerosis in an Italian population.
Neurobiology of aging - 1 May 2011
Fogh Isabella, D'Alfonso Sandra, Gellera Cinzia, Ratti Antonia, Cereda Cristina, Penco Silvana, Corrado Lucia, Sorarù Gianni, Castellotti Barbara, Tiloca Cinzia, Gagliardi Stella, Cozzi Lorena, Lupton Michelle K, Ticozzi Nicola, Mazzini Letizia, Shaw Chris E, Al-Chalabi Ammar, Powell John, Silani Vincenzo
Abstract excerpt
We have attempted to replicate a recently reported association of polymorphism rs10260404, in the Dipeptidyl-peptidase 6 gene (DPP6), with susceptibility to amyotrophic lateral sclerosis (ALS) in a large independent Italian cohort of 904 cases and 1036 controls. Minor allele frequency was 0.38 in cases and 0.39 in controls and no evidence of association with ALS was observed (P=0.638). Our negative results agree...
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