Glutathione S-transferase P1 single nucleotide polymorphism predicts permanent ototoxicity in children with medulloblastoma.

doi:10.1002/pbc.24366

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Article

Glutathione S-transferase P1 single nucleotide polymorphism predicts permanent ototoxicity in children with medulloblastoma.

Pediatric blood & cancer - 1 Apr 2013

Rednam Surya, Scheurer Michael E, Adesina Adekunle, Lau Ching C, Okcu Mehmet Fatih

Abstract excerpt

BACKGROUND: Glutathione S-transferase (GST) enzymes are involved in detoxifying chemotherapy and clearing reactive oxygen species formed by radiation. We explored the relationship between the host GSTP1 105 A > G polymorphism (rs1695), tumor GSTpi protein expression, and clinical outcomes in pediatric medulloblastoma. We hypothesized that the GSTP1 105 G-allele and increased tumor GSTpi expression would be...

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Identifiers

PMID: 23065688
DOI: 10.1002/pbc.24366
PMCID: PMC3549321

Genes

GSTP1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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