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Article

Glutathione S-transferase M1 and T1 polymorphisms may predict adverse effects after therapy in children with medulloblastoma.

Neuro-oncology - 1 Jun 2009

Barahmani Nadia, Carpentieri Sarah, Li Xio-Nan, Wang Tao, Cao Yumei, Howe Laura, Kilburn Lindsay, Chintagumpala Murali, Lau Ching, Okcu M Fatih

Abstract excerpt

Glutathione S-transferases (GSTs) are polymorphic enzymes that catalyze the glutathione conjugation of alkylating agents, platinum compounds, and free radicals formed by radiation used to treat medulloblastoma. We hypothesized that GST polymorphisms may be responsible, in part, for individual dif...

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Source

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Identifiers

PMID: 18952980
DOI: 10.1215/15228517-2008-089
PMCID: PMC2718973

Genes

GSTM1
GSTT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18952980-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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