Interactions of interleukin-12A and interleukin-12B polymorphisms on the risk of intracranial aneurysm.

doi:10.1007/s11033-012-2031-z

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Article

Interactions of interleukin-12A and interleukin-12B polymorphisms on the risk of intracranial aneurysm.

Molecular biology reports - 1 Dec 2012

Li Li-Juan, Pan Xin-Min, Sima Xiutian, Li Zhao-Hui, Zhang Lu-Shun, Sun Hong, Zhu Yi, Liang Wei-Bo, Gao Lin-Bo, Zhang Lin

Abstract excerpt

Several lines of evidence indicate that inflammatory processes play pivotal role in the development of intracranial aneurysm (IA). Recently, polymorphisms in the interleukin-12 (IL-12) gene were shown to be associated with immune-mediated inflammatory disease. The aim of this study was to investigate the interactions of IL-12A and IL-12B polymorphisms on the risk of IA in a Chinese population. A total of 422...

Topics

Case-Control Studies
Demography
Female
Gene Frequency
Genetic Predisposition to Disease
Humans
Interleukin-12 Subunit p35
Interleukin-12 Subunit p40
Intracranial Aneurysm
Male
Middle Aged
Polymorphism, Single Nucleotide
Risk Factors

Source

Open in PubMed

Identifiers

PMID: 23065210
DOI: 10.1007/s11033-012-2031-z

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