Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Crebanine, an aporphine alkaloid, induces cancer cell apoptosis through PI3K-Akt pathway in glioblastoma multiforme

4 Jun 2024

Abstract excerpt

Glioblastoma multiforme (GBM) is one of the most prevalent and lethal primary central nervous system malignancies. GBM is notorious for its high rates of recurrence and therapy resistance and the PI3K/Akt pathway plays a pivotal role in its malignant behavior. Crebanine (CB), an alkaloid capable of penetrating the blood–brain barrier (BBB), has been shown to have inhibitory effects on proinflammatory molecules...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenetics and DNA Methylation
Share to Glioma Diagnosis and Treatment
Share to MicroRNA in disease regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38895635
DOI: 10.3389/fphar.2024.1419044

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Crebanine, an aporphine alkaloid, induces cancer cell apoptosis through PI3K-Akt pathway in glioblastoma multiformePMID 38895635Read ↗

The Multi-Faceted Effect of Curcumin in Glioblastoma from Rescuing Cell Clearance to Autophagy-Independent EffectsSemantic proximity Read ↗

Exploring the therapeutic mechanisms and prognostic targets of Biochanin A in glioblastoma via integrated computational analysis and in vitro experimentsSemantic proximity Read ↗

Identification of thioridazine, an antipsychotic drug, as an antiglioblastoma and anticancer stem cell agent using public gene expression dataSemantic proximity Read ↗

Napabucasin, a novel STAT3 inhibitor suppresses proliferation, invasion and stemness of glioblastoma cellsSemantic proximity Read ↗

Exploring the Therapeutic Mechanisms and Prognostic Targets of Biochanin A in Glioblastoma via Network Pharmacology and Bioinformatics AnalysisSemantic proximity Read ↗

Cpne3 Regulates the Cell Proliferation and Apoptosis in Human Gbm via the Activation of Pi3k/akt Signaling PathwaySemantic proximity Read ↗

Targeting the insulin-like growth factor-1 receptor by picropodophyllin as a treatment option for glioblastomaSemantic proximity Read ↗

NRBP1 Promotes the Malignant Phenotypes of Glioblastoma by Regulating PI3K/Akt ActivationSemantic proximity Read ↗

Peiminine Inhibits Glioblastoma in Vitro and in Vivo Through Cell Cycle Arrest and Autophagic Flux BlockingSemantic proximity Read ↗

Targeting CREB for Cancer Therapy: Friend or FoeSemantic proximity Read ↗

Deciphering the Dose-Dependent Effects of Thymoquinone on Transcriptomic Changes and Cellular Proliferation in GlioblastomaSemantic proximity Read ↗

NRBP1 promotes malignant phenotypes of glioblastoma by regulating PI3K/Akt activation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.