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Article

Impaired impulse control is associated with a 5-HT2A receptor polymorphism in schizophrenia.

Psychiatry research - 30 Jul 2013

Tsuang Hui-Chun, Chen Wei J, Lin Sheng-Hsiang, Chen Teng-Yi, Chang Yi-Lin, Huang Kuo-Hao, Lane Hsien-Yuan

Abstract excerpt

The impact of the serotonin2a (5-HT2A) receptor gene on the pathophysiology of schizophrenia is inconclusive despite accumulating evidence implicating the 5-HT2A receptor. To simplify the complexity of genetic analysis, we used an endophenotype approach. The relationship between Continuous Performance Test (CPT) performance and 5-HT2A receptor gene variance was examined. Both patients with schizophrenia (n=255)...

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Identifiers

PMID: 23063294
DOI: 10.1016/j.psychres.2012.09.038

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