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Article

Differing clinical impact of BRCA1 and BRCA2 mutations in serous ovarian cancer.

Pharmacogenomics - 1 Oct 2012

Liu Guoyan, Yang Da, Sun Yan, Shmulevich Ilya, Xue Fengxia, Sood Anil K, Zhang Wei

Abstract excerpt

A key function of BRCA1 and BRCA2 is the participation in dsDNAbreak repair via homologous recombination. BRCA1 and BRCA2 mutations, which occur in most hereditary ovarian cancers (OCs) and approximately 10% of all OC cases, are associated with defects in homologous recombination and genomic instability, a phenotype termed 'BRCAness'. The clinical effects of BRCA1 and BRCA2 mutations have commonly been analyzed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23057551
DOI: 10.2217/pgs.12.137
PMCID: PMC3603383

Genes

BRCA2
BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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