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Article

BRCA1/2 Mutation Types Do Not Affect Prognosis in Ovarian Cancer Patients.

Current oncology (Toronto, Ont.) - 3 Nov 2021

Liontos Michalis, Zografos Eleni, Zoumpourlis Panagiotis, Andrikopoulou Angeliki, Svarna Anna, Fiste Oraianthi, Kunadis Elena, Papatheodoridi Alkistis Maria, Kaparelou Maria, Koutsoukos Konstantinos, Thomakos Nikoloas, Haidopoulos Dimitrios, Rodolakis Alexandros, Dimopoulos Meletios-Athanasios, Zagouri Flora

Abstract excerpt

BACKGROUND: High grade serous ovarian carcinoma (HGSOC) is the most lethal type of epithelial ovarian cancer, with a prevalence of germline BRCA1/2 mutations as high as 20%. Our objective is to determine whether the location of mutations in the different domains of the BRCA1/2 genes affects the clinical outcome of HGSOC patients. METHODS: A total of 51 women with BRCA1 or BRCA2 mutated ovarian cancer were...

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Identifiers

PMID: 34898566
DOI: 10.3390/curroncol28060377
PMCID: PMC8628789

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