Article
Ovarian cancer associated with inherited mutations in BRCA1 or BRCA2.
Current women's health reports - 1 Feb 2003
Swisher Elizabeth
Abstract excerpt
Most hereditary ovarian cancers are associated with germline mutations in the BRCA1 or BRCA2 genes. These genes are involved in many vital cellular functions, including DNA damage recognition, DNA repair, and control of transcription. Prophylactic oophorectomy is the most effective method of reducing ovarian cancer risk in women known to carry BRCA1 or BRCA2 mutations. Women with BRCA1-associated ovarian cancers...
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