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TNF-α -857 and -1031 polymorphisms predict good therapeutic response to TNF-α blockers in Chinese Han patients with ankylosing spondylitis.

Pharmacogenomics - 1 Oct 2012

Tong Qiang, Zhao Dong-Bao, Bajracharya Punam, Xu Xia, Kong Rui-Na, Zhang Ju, Dai Sheng-Ming, Cai Qing

Abstract excerpt

AIM: To evaluate whether polymorphisms at -857, -1031, -308 and -238 positions of the TNF-α gene influence response to TNF-α-blocker therapy in Chinese Han patients with ankylosing spondylitis. PATIENTS & METHODS: A total of 106 patients with ankylosing spondylitis were recruited and genotyped for -857, -1031, -308 and -238 TNF-α gene polymorphisms. In total, 32 received infliximab and 74 received a recombinant...

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PMID: 23057546
DOI: 10.2217/pgs.12.133

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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