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Regulation of Delta-Aminolevulinic Acid Dehydratase by Krüppel-Like Factor 1

3 Oct 2012

Abstract excerpt

Krüppel-like factor 1(KLF1) is a hematopoietic-specific zinc finger transcription factor essential for erythroid gene expression. In concert with the transacting factor GATA1, KLF1 modulates the coordinate expression of the genes encoding the multi-enzyme heme biosynthetic pathway during erythroid differentiation. To explore the mechanisms underpinning KLF1 action at the gene loci regulating the first 3 steps in...

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PMID: 23056320
DOI: 10.1371/journal.pone.0046482

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