Mutational effects depend on ploidy level: all else is not equal.

Abstract excerpt

Ploidy is predicted to influence adaptation directly, yet whether single mutations behave the same in different ploidy backgrounds has not been well studied. It has often been assumed theoretically that aside from dominance, selective parameters do not differ between cells of varying ploidy. Using the budding yeast Saccharomyces cerevisiae, I compared the effect size of 20 adaptive mutations in haploids and...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Antifungal Agents
• Share to Diploidy
• Share to Dose-Response Relationship, Drug