Article
Response to rivastigmine transdermal patch or memantine plus rivastigmine patch is affected by apolipoprotein E genotype in Alzheimer patients.
Dementia and geriatric cognitive disorders - 1 Jan 2012
Han Hyun Jeong, Kim Byeong C, Lee Jun-Young, Ryu Seung-Ho, Na Hae Ri, Yoon Soo Jin, Park Hyun Young, Shin Joon Hyun, Cho Soo-Jin, Yi Hyon-Ah, Choi Mun Seong, Heo Jae-Hyeok, Park Kyung Won, Kim Kwang K, Choi Seong Hye
Abstract excerpt
BACKGROUND/AIMS: The apolipoprotein E (APOE) genotype in response to pharmacological treatments in patients with Alzheimer's disease (AD) remains a matter of controversy. This analysis investigated the effect of the APOE genotype on the clinical response to rivastigmine transdermal patch monotherapy or memantine plus rivastigmine patch in patients with mild to moderate AD. METHODS: Two hundred and six (n = 206)...
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