Article
Genomic tests of variation in inbreeding among individuals and among chromosomes.
Genetics - 1 Dec 2012
Schraiber Joshua G, Shih Stephannie, Slatkin Montgomery
Abstract excerpt
We examine the distribution of heterozygous sites in nine European and nine Yoruban individuals whose genomic sequences were made publicly available by Complete Genomics. We show that it is possible to obtain detailed information about inbreeding when a relatively small set of whole-genome sequences is available. Rather than focus on testing for deviations from Hardy-Weinberg genotype frequencies at each site, we...
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