Article
Functional dissection of a mouse ribosomal protein promoter: significance of the polypyrimidine initiator and an element in the TATA-box region.
Proceedings of the National Academy of Sciences of the United States of America - 1 Feb 1990
Hariharan N, Perry R P
Abstract excerpt
All of the mammalian ribosomal protein (rp) genes examined to date initiate transcription with high precision despite the fact that they do not contain a well-defined TATA box. The initiation sites are situated within polypyrimidine tracts that are flanked by both upstream and intragenic promoter elements. In the TATA-box region of each rp promoter, there is a functionally critical element with nuclear factor...
Topics
- Animals
- Base Sequence
- Cloning, Molecular
- Gene Expression
- Genes
- Mice
- Molecular Sequence Data
- Mutation
- Nuclear Proteins
- Promoter Regions, Genetic
- Pyrimidines