Introduction of an initiator element in the mouse thymidylate synthase promoter alters S phase regulation but has no effect on promoter bidirectionality.

Abstract excerpt

The promoter of the mouse thymidylate synthase (TS) gene lacks a TATAA box and an initiator element, is bidirectional and initiates transcription at multiple start sites across broad initiation windows upstream and downstream of the 30 nt essential promoter region. The TS promoter also plays an essential role in the post-transcription regulation of TS gene expression during the G(1)-S phase transition. The goal...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cricetinae
• Share to Fibroblasts
• Share to Gene Expression Regulation, Enzymologic