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Article

Protection against Group A Streptococcus by Immunization with J8–Diphtheria Toxoid: Contribution of J8‐ and Diphtheria Toxoid–Specific Antibodies to Protection

15 May 2003

Abstract excerpt

A conformationally constrained, minimally conserved peptide from the M protein of group A streptococcus (GAS) has been defined. It consists of 12 amino acids from the C-repeat region within a non-M protein helix-forming sequence and is referred to as "J8." Here, we investigate the immunogenicity of a J8-diphtheria toxoid (DT) conjugate adjuvanted with the human-compatible adjuvants, SBAS2 and alum, and...

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Identifiers

PMID: 12721940
DOI: 10.1086/374800

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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