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Article

Stem and progenitor cell dysfunction in human trisomies.

EMBO reports - 1 Jan 2015

Liu Binbin, Filippi Sarah, Roy Anindita, Roberts Irene

Abstract excerpt

Trisomy 21, the commonest constitutional aneuploidy in humans, causes profound perturbation of stem and progenitor cell growth, which is both cell context dependent and developmental stage specific and mediated by complex genetic mechanisms beyond increased Hsa21 gene dosage. While proliferation of fetal hematopoietic and testicular stem/progenitors is increased and may underlie increased susceptibility to...

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Identifiers

PMID: 25520324
DOI: 10.15252/embr.201439583
PMCID: PMC4304728

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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