Article
Five-year surveillance of molecular markers of Plasmodium falciparum antimalarial drug resistance in Korogwe District, Tanzania: accumulation of the 581G mutation in the P. falciparum dihydropteroate synthase gene.
The American journal of tropical medicine and hygiene - 1 Apr 2009
Alifrangis Michael, Lusingu John P, Mmbando Bruno, Dalgaard Michael B, Vestergaard Lasse S, Ishengoma Deus, Khalil Insaf F, Theander Thor G, Lemnge Martha M, Bygbjerg Ib C
Abstract excerpt
In January 2007, Tanzania replaced sulfadoxine-pyrimethamine (SP) with artemether-lumefantrine for treatment of uncomplicated malaria. This study examined the impact of widespread SP use on molecular markers of Plasmodium falciparum drug resistance in blood samples from persons living in two villages in Korogwe District, Tanzania, from 2003 through 2007. The prevalence of the P. falciparum dihydropteroate...
Topics
- Animals
- Antimalarials
- Dihydropteroate Synthase
- Drug Resistance
- Genetic Markers
- Haplotypes
- Humans
- Malaria, Falciparum
- Mutation
- Plasmodium falciparum
- Population Surveillance
- Tanzania