Article
Inducible nitric oxide synthase haplotype associated with migraine and aura.
Molecular and cellular biochemistry - 1 May 2012
de O S Mansur Thiago, Gonçalves Flavia M, Martins-Oliveira Alisson, Speciali Jose G, Dach Fabiola, Lacchini Riccardo, Tanus-Santos Jose E
Abstract excerpt
Migraine is a complex neurological disorder with a clear neurogenic inflammatory component apparently including enhanced nitric oxide (NO) formation. Excessive NO amounts possibly contributing to migraine are derived from increased expression and activity of inducible NO synthase (iNOS). We tested the hypothesis that two functional, clinically relevant iNOS genetic polymorphisms (C(-1026)A-rs2779249 and...
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