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Article

Narrow groove and restricted anchors of MHC class I molecule BF2*0401 plus peptide transporter restriction can explain disease susceptibility of B4 chickens.

Journal of immunology (Baltimore, Md. : 1950) - 1 Nov 2012

Zhang Jianhua, Chen Yong, Qi Jianxun, Gao Feng, Liu Yanjie, Liu Jun, Zhou Xuyu, Kaufman Jim, Xia Chun, Gao George F

Abstract excerpt

The MHC has genetic associations with many diseases, often due to differences in presentation of antigenic peptides by polymorphic MHC molecules to T lymphocytes of the immune system. In chickens, only a single classical class I molecule in each MHC haplotype is expressed well due to coevolution with the polymorphic TAPs which means that resistance and susceptibility to infectious pathogens are particularly easy...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23041567
DOI: 10.4049/jimmunol.1200885
PMCID: PMC5018395

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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