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Article

A Wider and Deeper Peptide-Binding Groove for the Class I Molecules from B15 Compared with B19 Chickens Correlates with Relative Resistance to Marek's Disease.

Journal of immunology (Baltimore, Md. : 1950) - 1 Mar 2023

Han Lingxia, Wu Shaolian, Zhang Ting, Peng Weiyu, Zhao Min, Yue Can, Wen Wanxin, Cai Wenbo, Li Min, Wallny Hans-Joachim, Avila David W, Mwangi William, Nair Venugopal, Ternette Nicola, Guo Yaxin, Zhao Yingze, Chai Yan, Qi Jianxun, Liang Hao, Gao George F, Kaufman Jim, Liu William J

Abstract excerpt

The chicken MHC is known to confer decisive resistance or susceptibility to various economically important pathogens, including the iconic oncogenic herpesvirus that causes Marek's disease (MD). Only one classical class I gene, BF2, is expressed at a high level in chickens, so it was relatively easy to discern a hierarchy from well-expressed thermostable fastidious specialist alleles to promiscuous generalist...

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Identifiers

PMID: 36695776
DOI: 10.4049/jimmunol.2200211
PMCID: PMC7614295

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A Wider and Deeper Peptide-Binding Groove for the Class I Molecules from B15 Compared with B19 Chickens Correlates with Relative Resistance to Marek's Disease.PMID 36695776Read ↗

Minor differences in peptide presentation between chicken MHC class I molecules can explain differences in disease susceptibilitySemantic proximity Read ↗

The dominantly expressed class II molecule from a resistant MHC haplotype presents only a few Marek’s disease virus peptides by using an unprecedented binding motifSemantic proximity Read ↗

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Simplifying principles underlying the highly complex peptide motif of the promiscuous chicken MHC class I molecule, BF2*21:01Semantic proximity Read ↗

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