Article
Oxidative stress-regulated lentiviral TK/GCV gene therapy for lung cancer treatment.
Cancer research - 1 Dec 2012
Leinonen Hanna M, Ruotsalainen Anna-Kaisa, Määttä Ann-Marie, Laitinen Heidi M, Kuosmanen Suvi M, Kansanen Emilia, Pikkarainen Jere T, Lappalainen Jari P, Samaranayake Haritha, Lesch Hanna P, Kaikkonen Minna U, Ylä-Herttuala Seppo, Levonen Anna-Liisa
Abstract excerpt
Nuclear factor erythroid-2 related factor 2 (Nrf2) is a transcription factor that regulates protection against a wide variety of toxic insults to cells, including cytotoxic cancer chemotherapeutic drugs. Many lung cancer cells harbor a mutation in either Nrf2 or its inhibitor Keap1 resulting in permanent activation of Nrf2 and chemoresistance. In this study, we sought to examine whether this attribute could be...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.