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Keap1 recognizes EIAV early accessory protein Rev to promote antiviral defense

9 Feb 2022

Abstract excerpt

The Nrf2/Keap1 axis plays a complex role in viral susceptibility, virus-associated inflammation and immune regulation in host cells. However, whether or how the Nrf2/Keap1 axis is involved in the interactions between equine lentiviruses and their hosts remains unclear. Here, we demonstrate that the Nrf2/Keap1 axis was activated during EIAV infection. Mechanistically, EIAV-Rev competitively binds to Keap1 and...

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PMID: 35139135
DOI: 10.1371/journal.ppat.1009986

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