Article
Biosynthesis, maturation, and acid activation of the Semliki Forest virus fusion protein.
Journal of virology - 1 Oct 1990
Kielian M, Jungerwirth S, Sayad K U, DeCandido S
Abstract excerpt
The Semliki Forest virus spike protein has a potent membrane fusion activity which is activated in vivo by the low pH of endocytic vacuoles. The spike protein is composed of two transmembrane subunits, E1 and E2, plus E3, a peripheral polypeptide. Acid-induced conformational changes in the E1 or...
Topics
- Acetylglucosaminidase
- Animals
- Cell Line
- Cell Transformation, Viral
- Fluorescent Antibody Technique
- Hydrogen-Ion Concentration
- Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase
- Membrane Fusion
- Mutation
- Protein Conformation
- Semliki forest virus
- Viral Fusion Proteins