Article
Genetic variants of the renin-angiotensin-aldosterone system and reverse remodeling after cardiac resynchronization therapy.
Journal of cardiac failure - 1 Oct 2012
De Maria Renata, Landolina Maurizio, Gasparini Maurizio, Schmitz Boris, Campolo Jonica, Parolini Marina, Sanzo Antonio, Galimberti Paola, Bianchi Michele, Brand Stefan-Martin, Parodi Oberdan, Lunati Maurizio
Abstract excerpt
BACKGROUND: Reverse remodeling (RR) after cardiac resynchronization therapy (CRT) is associated with favorable clinical outcomes in heart failure (HF). The renin-angiotensin-aldosterone system (RAAS) is involved in the remodeling process. METHODS AND RESULTS: We assessed the association between RR and 8 common RAAS gene variants, which were determined by TaqMan assays, in 156 outpatients with chronic HF. RR was...
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