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Article

Refractory hyperaldosteronism in heart failure is associated with plasma renin activity and angiotensinogen polymorphism.

Journal of cardiovascular medicine (Hagerstown, Md.) - 1 Jun 2015

Vergaro Giuseppe, Fatini Cinzia, Sticchi Elena, Vassalle Cristina, Gensini Gianfranco, Ripoli Andrea, Rossignol Patrick, Passino Claudio, Emdin Michele, Abbate Rosanna

Abstract excerpt

AIMS: Refractory hyperaldosteronism is frequently observed in heart failure patients on up-to-date treatment, and holds prognostic value. Our aim was to identify which factors, either genetic or nongenetic, are associated with refractory hyperaldosteronism. METHODS: We enrolled 109 consecutive patients with left ventricular systolic dysfunction [left ventricular ejection fraction (LVEF) 32 ± 10%; 86% males; age...

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Source

Identifiers

PMID: 25036270
DOI: 10.2459/JCM.0000000000000156

Genes

AGT
ACE
AGTR1
REN

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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