Adverse outcomes in clear cell renal cell carcinoma with mutations of 3p21 epigenetic regulators BAP1 and SETD2: a report by MSKCC and the KIRC TCGA research network.

doi:10.1158/1078-0432.CCR-12-3886

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Article

Adverse outcomes in clear cell renal cell carcinoma with mutations of 3p21 epigenetic regulators BAP1 and SETD2: a report by MSKCC and the KIRC TCGA research network.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jun 2013

Hakimi A Ari, Ostrovnaya Irina, Reva Boris, Schultz Nikolaus, Chen Ying-Bei, Gonen Mithat, Liu Han, Takeda Shugaku, Voss Martin H, Tickoo Satish K, Reuter Victor E, Russo Paul, Cheng Emily H, Sander Chris, Motzer Robert J, Hsieh James J

Abstract excerpt

PURPOSE: To investigate the impact of newly identified chromosome 3p21 epigenetic tumor suppressors PBRM1, SETD2, and BAP1 on cancer-specific survival (CSS) of 609 patients with clear cell renal cell carcinoma (ccRCC) from 2 distinct cohorts. EXPERIMENTAL DESIGN: Select sequencing on 3p tumor suppressors of 188 patients who underwent resection of primary ccRCC at the Memorial Sloan-Kettering Cancer Center (MSKCC)...

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Identifiers

PMID: 23620406
DOI: 10.1158/1078-0432.CCR-12-3886
PMCID: PMC3708609

Genes

BAP1
SETD2
PBRM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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