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Article

Modification of the inflammatory mediator LRRFIP2 by the ubiquitin-like protein FAT10 inhibits its activity during cellular response to LPS.

Biochemical and biophysical research communications - 9 Nov 2012

Buchsbaum Samuel, Bercovich Beatrice, Ziv Tamar, Ciechanover Aaron

Abstract excerpt

FAT10 is a ubiquitin-like protein made of two tandem, head-to-tail, ubiquitin domains. It is known to covalently modify proteins in a mechanism similar, though not identical, to that of other ubiquitin-like proteins. The lack of known physiological substrates covalently conjugated by the protein made it difficult to unravel its biological functions. Here we identify two proteins that are covalently modified by...

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Source

Identifiers

PMID: 23036196
DOI: 10.1016/j.bbrc.2012.09.110

Genes

LRRFIP2
MYD88
TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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