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Article

Transforming a drug/H+ antiporter into a polyamine importer by a single mutation.

Proceedings of the National Academy of Sciences of the United States of America - 16 Oct 2012

Brill Shlomo, Falk Ofir Sade, Schuldiner Shimon

Abstract excerpt

EmrE, a multidrug antiporter from Escherichia coli, has presented biochemists with unusual surprises. Here we describe the transformation of EmrE, a drug/H(+) antiporter to a polyamine importer by a single mutation. Antibiotic resistance in microorganisms may arise by mutations at certain chromosomal loci. To investigate this phenomenon, we used directed evolution of EmrE to assess the rate of development of...

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Identifiers

PMID: 23035252
DOI: 10.1073/pnas.1211831109
PMCID: PMC3479526

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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