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Article

Evolution of polyamine resistance in Staphylococcus aureus through modulation of potassium transport.

mSphere - 30 Sept 2025

Campbell Killian, Kowalski Caitlin H, Kohler Kristin M, Kebret Mara R, Barber Matthew F

Abstract excerpt

Microbes must adapt to diverse biotic and abiotic factors encountered in host environments. Polyamines are an abundant class of aliphatic molecules that play essential roles in fundamental cellular processes across the tree of life. Surprisingly, the bacterial pathogen Staphylococcus aureus is highly sensitive to polyamines encountered during infection, and acquisition of a polyamine resistance locus has been...

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Identifiers

PMID: 40824070
DOI: 10.1128/msphere.00613-24
PMCID: PMC12482181

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