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Article

A fundamental protein property, thermodynamic stability, revealed solely from large-scale measurements of protein function.

Proceedings of the National Academy of Sciences of the United States of America - 16 Oct 2012

Araya Carlos L, Fowler Douglas M, Chen Wentao, Muniez Ike, Kelly Jeffery W, Fields Stanley

Abstract excerpt

The ability of a protein to carry out a given function results from fundamental physicochemical properties that include the protein's structure, mechanism of action, and thermodynamic stability. Traditional approaches to study these properties have typically required the direct measurement of the...

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Identifiers

PMID: 23035249
DOI: 10.1073/pnas.1209751109
PMCID: PMC3479514

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23035249-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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