Article
The structure of the T127L/S128A mutant of cAMP receptor protein facilitates promoter site binding.
The Journal of biological chemistry - 6 Apr 2001
Chu S Y, Tordova M, Gilliland G L, Gorshkova I, Shi Y, Wang S, Schwarz F P
Abstract excerpt
The x-ray crystal structure of the cAMP-ligated T127L/S128A double mutant of cAMP receptor protein (CRP) was determined to a resolution of 2.2 A. Although this structure is close to that of the x-ray crystal structure of cAMP-ligated CRP with one subunit in the open form and one subunit in the closed form, a bound syn-cAMP is clearly observed in the closed subunit in a third binding site in the C-terminal domain....
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