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Article

Structural basis for cAMP-mediated allosteric control of the catabolite activator protein.

Proceedings of the National Academy of Sciences of the United States of America - 28 Apr 2009

Popovych Nataliya, Tzeng Shiou-Ru, Tonelli Marco, Ebright Richard H, Kalodimos Charalampos G

Abstract excerpt

The cAMP-mediated allosteric transition in the catabolite activator protein (CAP; also known as the cAMP receptor protein, CRP) is a textbook example of modulation of DNA-binding activity by small-molecule binding. Here we report the structure of CAP in the absence of cAMP, which, together with structures of CAP in the presence of cAMP, defines atomic details of the cAMP-mediated allosteric transition. The...

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Share to Apoproteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cyclic AMP

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Share to Nuclear Magnetic Resonance, Biomolecular

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Source

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Identifiers

PMID: 19359484
DOI: 10.1073/pnas.0900595106
PMCID: PMC2678429

Genes

CRP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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