Article
Relationship between glutathione S-transferase M1 polymorphism and clinical outcomes in Chinese peritoneal dialysis patients.
Journal of nephrology - 1 Jan 2000
Poon Peter Yam-Kau, Szeto Cheuk-Chun, Kwan Bonnie Ching-Ha, Chow Kai-Ming, Li Philip Kam-Tao
Abstract excerpt
BACKGROUND: Oxidative stress contributes to cardiovascular diseases in peritoneal dialysis (PD) patients. Glutathione S-transferase M1 is an antioxidative enzyme encoded by the GST M1 gene. The GST M1 (-) genotype causes deficiency of the enzyme when compared with the GST M1 (+) genotype. We investigated the effects of the GST M1 (-)/(+) polymorphism on the clinical outcomes of Chinese PD patients. METHODS: We...
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