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LRpath analysis reveals common pathways dysregulated via DNA methylation across cancer types

4 Oct 2012

Abstract excerpt

BACKGROUND: The relative contribution of epigenetic mechanisms to carcinogenesis is not well understood, including the extent to which epigenetic dysregulation and somatic mutations target similar genes and pathways. We hypothesize that during carcinogenesis, certain pathways or biological gene sets are commonly dysregulated via DNA methylation across cancer types. The ability of our logistic regression-based...

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PMID: 23033966
DOI: 10.1186/1471-2164-13-526

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