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Article

Molecular characterization of the viaB locus encoding the biosynthetic machinery for Vi capsule formation in Salmonella Typhi.

PloS one - 1 Jan 2012

Wetter Michael, Goulding David, Pickard Derek, Kowarik Michael, Waechter Charles J, Dougan Gordon, Wacker Michael

Abstract excerpt

The Vi capsular polysaccharide (CPS) of Salmonella enterica serovar Typhi, the cause of human typhoid, is important for infectivity and virulence. The Vi biosynthetic machinery is encoded within the viaB locus composed of 10 genes involved in regulation of expression (tviA), polymer synthesis (tviB-tviE), and cell surface localization of the CPS (vexA-vexE). We cloned the viaB locus from S. Typhi and transposon...

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Identifiers

PMID: 23029132
DOI: 10.1371/journal.pone.0045609
PMCID: PMC3448643

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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