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Article

A genomewide mutagenesis screen identifies multiple genes contributing to Vi capsular expression in Salmonella enterica serovar Typhi.

Journal of bacteriology - 1 Mar 2013

Pickard Derek, Kingsley Robert A, Hale Christine, Turner Keith, Sivaraman Karthikeyan, Wetter Michael, Langridge Gemma, Dougan Gordon

Abstract excerpt

A transposon-based, genomewide mutagenesis screen exploiting the killing activity of a lytic ViII bacteriophage was used to identify Salmonella enterica serovar Typhi genes that contribute to Vi polysaccharide capsule expression. Genes enriched in the screen included those within the viaB locus (tviABCDE and vexABCDE) as well as oxyR, barA/sirA, and yrfF, which have not previously been associated with Vi...

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Identifiers

PMID: 23316043
DOI: 10.1128/JB.01632-12
PMCID: PMC3592008

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Source receipt: pubmed, retrieved 7 Sept 2026.

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