The Type IVB Pili of Salmonella enterica Serovar Typhi Bind to the Cystic Fibrosis Transmembrane Conductance Regulator

doi:10.1128/iai.71.10.6049-6050.2003

Article

The Type IVB Pili of Salmonella enterica Serovar Typhi Bind to the Cystic Fibrosis Transmembrane Conductance Regulator

19 Sept 2003

Abstract excerpt

Salmonella enterica serovar Typhi expresses type IVB pili. We show that the prePilS protein (the soluble precursor form of the structural pilin) interacts with a 15-mer peptide representing the first extracellular domain of the cystic fibrosis transmembrane conductance regulator (CFTR), a recognized human epithelial cell receptor for serovar Typhi (G. B. Pier et al., Nature 393:79-82, 1998). This indicates that...

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