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Contamination of clinical specimens with MLV-encoding nucleic acids: implications for XMRV and other candidate human retroviruses

1 Dec 2010

Abstract excerpt

Efforts to assess the prevalence of xenotropic murine leukemia virus-related virus (XMRV) in patients with prostate cancer and chronic fatigue syndrome have relied heavily on PCR-based testing of clinical samples and have yielded widely divergent findings. This week in Retrovirology, reports from four independent research groups illustrate the extreme care needed to exclude DNA or RNA contamination in PCR...

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PMID: 21171980
DOI: 10.1186/1742-4690-7-112

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Research trail→

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Contamination of clinical specimens with MLV-encoding nucleic acids: implications for XMRV and other candidate human retrovirusesPMID 21171980Read ↗

In-depth investigation of archival and prospectively collected samples reveals no evidence for XMRV infection in prostate cancer.Semantic proximity Read ↗

Disease-associated XMRV sequences are consistent with laboratory contaminationSemantic proximity Read ↗

Mouse DNA contamination in human tissue tested for XMRVSemantic proximity Read ↗

No evidence of XMRV in prostate cancer cohorts in the Midwestern United States.Semantic proximity Read ↗

Biology and pathophysiology of the new human retrovirus XMRV and its association with human disease.Semantic proximity Read ↗

Contamination of human DNA samples with mouse DNA can lead to false detection of XMRV-like sequencesSemantic proximity Read ↗

DNA Extraction Columns Contaminated with Murine SequencesSemantic proximity Read ↗

Multiple sources of contamination in samples from patients reported to have XMRV infection.Semantic proximity Read ↗

No association of xenotropic murine leukemia virus-related viruses with prostate cancer.Semantic proximity Read ↗

Multiple Integrated Copies and High-Level Production of the Human Retrovirus XMRV (Xenotropic Murine Leukemia Virus-Related Virus) from 22Rv1 Prostate Carcinoma CellsSemantic proximity Read ↗

Xenotropic Murine Leukemia Virus–related Gammaretrovirus in Respiratory TractSemantic proximity Read ↗

Nucleic Acid, Antibody, and Virus Culture Methods to Detect Xenotropic MLV-Related Virus in Human Blood SamplesSemantic proximity Read ↗

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