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Article

[The role of myocilin in the pathogenesis of primary open-angle glaucoma].

Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft - 1 Sept 2002

Ohlmann A, Tamm E R

Abstract excerpt

Mutations in myocilin are responsible for autosomal-dominant inherited juvenile open-angle glaucoma and some subgroups of adult-onset glaucoma (POAG). Myocilin is a secreted glycoprotein with a molecular weight of approximately 55-57 kDa that forms dimers and multimers. Structural motives are domains that have similarities with myosin and olfactomedin, a signalling sequence as well as a leucine zipper at the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12219254
DOI: 10.1007/s00347-002-0699-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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[The role of myocilin in the pathogenesis of primary open-angle glaucoma].PMID 12219254Read ↗

The effects of myocilin expression on functionally relevant trabecular meshwork genes: a mini-review.Semantic proximity Read ↗

Glaucoma-associated myocilin: a better understanding but much more to learn.Semantic proximity Read ↗

Keeping an Eye on Myocilin: A Complex Molecule Associated with Primary Open-Angle Glaucoma SusceptibilitySemantic proximity Read ↗

Functional analysis of the glaucoma-causing TIGR/myocilin protein: integrity of amino-terminal coiled-coil regions and olfactomedin homology domain is essential for extracellular adhesion and secretion.Semantic proximity Read ↗

[A preliminary study on gene mutation and its function in a large family (GZ.1 pedigree) with open-angle glaucoma].Semantic proximity Read ↗

New mutation in the myocilin gene segregates with juvenile-onset open-angle glaucoma in a Brazilian family.Semantic proximity Read ↗

In vitro and in vivo study on the secretion of the Gly367Arg mutant myocilin protein.Semantic proximity Read ↗

Serine to proline mutation at position 341 of MYOC impairs trabecular meshwork function by causing autophagy deregulationSemantic proximity Read ↗

Myocilin glaucoma.Semantic proximity Read ↗

Cystatin a, a potential common link for mutant myocilin causative glaucoma.Semantic proximity Read ↗

Expression of Mutant Myocilin Induces Abnormal Intracellular Accumulation of Selected Extracellular Matrix Proteins in the Trabecular Meshwork.Semantic proximity Read ↗

The genetics of open-angle glaucoma: the story of GLC1A and myocilin.Semantic proximity Read ↗

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