Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pro370Leu mutant myocilin impairs mitochondrial functions in human trabecular meshwork cells.

Molecular vision - 1 Jan 2009

He Yuan, Leung Kar Wah, Zhuo Ye-Hong, Ge Jian

Abstract excerpt

PURPOSE: Oxidative stress is a risk factor for the onset and progression of primary open-angle glaucoma (POAG), but the exact molecular basis remains unknown. Here, we investigated the mechanisms for Pro370Leu mutant myocilin to induce mitochondrial dysfunction and subsequent reactive oxygen species (ROS) generation in trabecular meshwork (TM) cells obtained from POAG individuals. METHODS: Primary non-diseased...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Triphosphate
Share to Cell Death
Share to Eye Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glaucoma, Open-Angle

Share to Glycoproteins

Share to Membrane Potential, Mitochondrial

Share to Microscopy, Confocal

Share to Trabecular Meshwork

Source

Open in PubMed Open full text

Identifiers

PMID: 19390644
PMCID: PMC2672150

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pro370Leu mutant myocilin impairs mitochondrial functions in human trabecular meshwork cells.PMID 19390644Read ↗

Pro370Leu mutant myocilin disturbs the endoplasm reticulum stress response and mitochondrial membrane potential in human trabecular meshwork cells.Semantic proximity Read ↗

Myocilin Gene Mutation Induced Autophagy Activation Causes Dysfunction of Trabecular Meshwork CellsSemantic proximity Read ↗

Expression of myocilin mutants sensitizes cells to oxidative stress-induced apoptosis: implication for glaucoma pathogenesis.Semantic proximity Read ↗

Accumulation of Asn450Tyr mutant myocilin in ER promotes apoptosis of human trabecular meshwork cells.Semantic proximity Read ↗

MYOC/p.G367R mutation induces cell dysfunction of the trabecular meshwork and retina via impairment of the protein degradation mechanismSemantic proximity Read ↗

Accumulation of mutant myocilins in ER leads to ER stress and potential cytotoxicity in human trabecular meshwork cells.Semantic proximity Read ↗

CRISPR-Cas9–based treatment of myocilin-associated glaucomaSemantic proximity Read ↗

[A preliminary study on gene mutation and its function in a large family (GZ.1 pedigree) with open-angle glaucoma].Semantic proximity Read ↗

Protein misfolding and mitochondrial dysfunction in glaucomaSemantic proximity Read ↗

Aggregated myocilin induces russell bodies and causes apoptosis: implications for the pathogenesis of myocilin-caused primary open-angle glaucoma.Semantic proximity Read ↗

The effects of myocilin expression on functionally relevant trabecular meshwork genes: a mini-review.Semantic proximity Read ↗

Human Pro370Leu Mutant Myocilin Induces the Phenotype of Open-Angle Glaucoma in Transgenic Mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.